The Syntheses,Structures, Fluorescence Properties and Biological Activity of two Novel Zinc(II) Complexes Controlled by the Tripodal Imidazole Ligand期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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The Syntheses,Structures, Fluorescence Properties and Biological Activity of two Novel Zinc(II) Complexes Controlled by the Tripodal Imidazole Ligand

Authors:	Email author" target="_blank">En-Jun?Gao Email author Shaozhong?Zhang Yang?Meng Fu-Chen?Zhao Xiao-Yu?Ma Hai-Tao?Jin Si-Jia?Liu Jing?Ge Ya-Guang?Sun Wan-zhong?Zhang Email author" target="_blank">Ming-Chang?Zhu Email author

Institution:	1.The key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry,Shenyang University of Chemical Technology,Shenyang,China

Abstract:	Two new zinc complexes, namely Zn(L¹)ClCH₂NO(1) and {Zn(L²)CH₂NO}_n?N(CH₃)₃?ClO₄(2) (L¹ = 3,5-di(1H-imidazol-1-yl)pyridine L² = 1,3,5-tris(1-imidazolyl) benzene), have been synthesized, and characterized by IR spectra, elemental analysis, and a single crystal X-ray diffraction. Fluorescence spectroscopy indicated that two complexes presented strong DNA binding affinity constants to fish sperm DNA (FS-DNA). Gel electrophoresis assay demonstrated the ability of the complex to cleave the HL-60 DNA. Apoptotic study showed the complex exhibited significant cancer cell(KB) inhibitory rate.

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