Mononuclear transition and non-transition complexes of amlodipine besylate as antihypertensive agent: synthesis,spectral, thermal,and antimicrobial studies |
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Authors: | Email author" target="_blank">Moamen?S?RefatEmail author Foziah?A?Al-Saif |
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Institution: | 1.Department of Chemistry, Faculty of Science,Port Said University,Port Said,Egypt;2.Department of Chemistry, Faculty of Science,Taif University,Taif,Saudi Arabia;3.Department of Chemistry, Faculty of Science,Princess Nora Bint Abdul Rahman University,Riyadh,Saudi Arabia |
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Abstract: | Mononuclear Mn(II), Co(II), Ni(II), Zn(II), Cd(II), Mg(II), Sr(II), Ba(II), Ca(II), Pt(IV), Au(III), and Pd(II) complexes of the drug amlodipine besylate (HL) have been synthesized and characterized by elemental analysis, spectroscopic technique (IR, UV–Vis, solid reflectance, scanning electron microscopy, X-ray powder diffraction, and 1H-NMR) and magnetic measurements. The elemental analyses of the complexes are confirmed by the stoichiometry of the types M(HL)(X)2(H2O)]·nH2O M = Mn(II), Co(II), Zn(II), Ni(II), Mg(II), Sr(II), Ba(II), and Ca(II); X = Cl? or NO3 ?], Cd(HL)(H2O)]Cl2, Pd(HL)2]Cl2, Pt(L)2]Cl2, and Au(L)2]Cl, respectively. Infrared data revealed that the amlodipine besylate drug ligand chelated as monobasic tridentate through NH2, oxygen (ether), and OH of besylate groups in Mn(II), Co(II), Ni(II), Zn(II), Cd(II), Mg(II), Sr(II), Ba(II), Ca(II), and Au(III) complexes, but in Pt(IV) and Pd(II) complexes, the amlodipine besylate coordinates via NH2 and OH (besylate) groups. An octahedral geometry is proposed for all complexes except for the Cd(II), Pt(IV), and Pd(II) complexes. The amlodipine besylate free ligand and the transition and non-transition complexes showed antibacterial activity towards some Gram-positive and Gram-negative bacteria and the fungi (Aspergillus flavus and Candida albicans). |
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