Mixed Ligand Complex Formation of Cetirizine Drug with Bivalent Transition Metal(II) Ions in the Presence of 2-Aminomethylbenzimidazole: Synthesis,Structural, Biological,pH-Metric and Thermodynamic Studies |
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Authors: | Abeer?T?Abdelkarim Mohammed?M?Al-Shomrani Email author" target="_blank">Ahmed?M?RayanEmail author Ahmed?A?El-Sherif |
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Institution: | 1.Department of Chemistry, Faculty of Science,Cairo University,Giza,Egypt;2.Department of Mathematics, Faculty of Science,King Abdulaziz University,Jeddah,Kingdom of Saudi Arabia;3.Department of Chemistry, Faculty of Arts and Science,Northern Border University,Rafha-156,Kingdom of Saudi Arabia;4.Department of Science and Mathematics, Faculty of Education,University of Assiut,The New Valley,Egypt |
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Abstract: | Mononuclear copper(II), cobalt(II) and nickel(II) complexes of cetirizine (CTZ = 2-2-4-(4-chlorophenyl)phenyl methyl]-piperazine-1-yl]-ethoxy]acetic acid) in the presence of 2-aminomethyl-benzimidazole·2HCl (AMBI), as a representative example of heterocyclic bases, were synthesized and studied by different physical techniques. All mixed-ligand complexes have been fully characterized with the help of elemental analyses, molecular weight determinations, molar conductance, magnetic moments and spectroscopic data. The formulae of the isolated complexes are M(AMBI)(CTZ)(NO3)(H2O)2]·nH2O where AMBI is the neutral bidentate 2-aminomethylbenzimidazole, CTZ the deprotonated cetirizine and n = 1 for Co(II) or 0 for Cu(II) and Ni(II) complexes. The measured molar conductance values in DMSO indicate that the complexes are non-electrolytes. The formation equilibria of the ternary complexes have been investigated. Ternary complexes are formed by a simultaneous mechanism. Stoichiometry and stability constants for the complexes formed are reported. The concentration distribution of the complexes in solution was evaluated as a function of pH. The thermodynamic parameters were calculated from the temperature dependence of the equilibrium constants and are discussed. The synthesized metal chelates have been screened for their antimicrobial activities against the selected types of Gram-positive (G+) and Gram-negative (G?) bacteria. They were found to be more active against Gram positive than Gram negative bacteria. The antimicrobial activity in terms of metal ions obeys this order: Cu(II) > Ni(II) > Co(II). |
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