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| CdX(X=Se,Te,Te/ZnS)量子点脂质体的制备及毒性比较 | |
| 引用本文： | 王显祥,杨中科,郭 敏,刘 怡,黄 娟,单 志,杨婉身.CdX(X=Se,Te,Te/ZnS)量子点脂质体的制备及毒性比较[J].无机化学学报,2009,25(3):496-500. |
| 作者姓名： | 王显祥 杨中科 郭 敏 刘 怡 黄 娟 单 志 杨婉身 |
| 作者单位： | 1. 四川农业大学生命科学与理学院,雅安,625014;四川大学化学系,成都,610041 2. 四川农业大学动物医学院,雅安,625014 3. 四川农业大学生命科学与理学院,雅安,625014 |
| 基金项目： | 四川农业大学引进人才基金，四川省教育厅自然科学科研重点项目 |
| 摘 要： | 在水相中以巯基乙酸(mercaptoacetic acid, MA)为稳定剂合成了CdSe、CdTe、CdTe/ZnS量子点及谷胱甘肽(glutathione, GSH)为稳定剂合成了CdTe量子点，然后通过卵磷脂和胆固醇修饰制得相应的量子点脂质体。溶血实验证实GSH修饰量子点的溶血率低于MA修饰的量子点45%；脂质体修饰后，量子点的溶血率＜5%，达到生物医用材料要求。不同表面修饰的量子点对小鼠毒性存在明显差异，荧光显微镜观察组织切片证实量子点在小鼠体内主要分布在肺、肾、胸腺等组织中，而脂质体量子点在脑组 |
| 关 键 词： | CdX量子点 脂质体量子点 溶血 毒性 |
Preparation of CdX(X=Se, Te, Te/Zns) Quantum Dots Liposome and Comparison of Toxicity in Vitro and in Vivo |
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| WANG Xian-Xiang,YANG Zhong-Ke,GUO Min,LIU Yi,HUANG Juan,SAN Zhi and YANG Wan-Shen.Preparation of CdX(X=Se, Te, Te/Zns) Quantum Dots Liposome and Comparison of Toxicity in Vitro and in Vivo[J].Chinese Journal of Inorganic Chemistry,2009,25(3):496-500. | |
| Authors: | WANG Xian-Xiang YANG Zhong-Ke GUO Min LIU Yi HUANG Juan SAN Zhi and YANG Wan-Shen |
| Abstract: | Mercaptoacetic acid(MA) capped CdSe, CdTe, CdTe/ZnS quantum dots(QDs) and glutathione(GSH) QDs were prepared in water phase; then quantum dots liposome(QD-LP) were synthesized by modifying QDs surface with lecithin and cholesterol. In vitro hemolysis tested, the hemolysis rate of GSH-capped QDs was lower 45% than MA-capped QDs, and QD-LP was less than 5%, which meet the requirements of biomedical materials. The toxicity in vivo was tested with tissue section by fluorescence microscope. It showed that different surface-modified QDs had different toxicity in mice. QDs were distributed mainly in the lung, kidney and thymus tissues, but QD-LP mainly existed in the brain tissues. |
| Keywords: | CdX quantum dots quantum dots liposome hemolysis toxicity |
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