Gadolinium-doped LipoCEST agents: a potential novel class of dual 1H-MRI probes |
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| Authors: | Terreno Enzo Boffa Cinzia Menchise Valeria Fedeli Franco Carrera Carla Castelli Daniela Delli Digilio Giuseppe Aime Silvio |
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| Affiliation: | Department of Chemistry IFM and Molecular & Preclinical Imaging Centres, University of Torino, via Nizza 52, 10126, Torino, Italy. enzo.terreno@unito.it |
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| Abstract: | A novel class of paramagnetic liposome-based systems acting as dual T(1) and CEST (1)H-MRI contrast agents is described. The vesicles contain a shift reagent in the aqueous core and a Gd-complex on the external surface conjugated through a biodegradable linker. As such, the probe can generate T(1) contrast only, but after the cleavage and removal of the Gd-coating, the CEST contrast is switched on. |
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