Total synthesis of lucilactaene, a cell cycle inhibitor active in p53-inactive cells |
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| Authors: | Coleman Robert S Walczak Matthew C Campbell Erica L |
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| Affiliation: | Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210-1185, USA. coleman@chemistry.ohio-state.edu |
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| Abstract: | Hetero-bis-metalated 1,3-butadiene is employed in the lynchpin coupling of synthetic fragments of the side chain of the antitumor agent, lucilactaene. Sequential Stille and Suzuki-Miyaura couplings interpolate this unique boron/tin diene into the pentaene chain. The total synthesis of lucilactaene was accomplished efficiently, in just eight linear steps. |
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