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Synthesis of unnatural cyclitols via a combined enzymatic-palladium catalysis approach |
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| Authors: | Ana Bellomo,Hè lio A. Stefani |
| Affiliation: | a Departamento de Química Orgánica, Facultad de Química, UdelaR, General Flores 2124, C.C. 1157 Montevideo, Uruguay b Departamento de Farmácia, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, SP, Brazil |
| Abstract: | The Suzuki-Miyaura cross-coupling reaction of a hydroxylated vinyl bromide obtained by a chemoenzymatic approach with a diverse range of potassium organotrifluoroborates has been accomplished catalyzed by Pd(PPh3)4 in satisfactory yields. A variety of functional groups are tolerated in the nucleophilic partner. |
| Keywords: | Suzuki-Miyaura cross-coupling reaction Potassium organotrifluoroborate salts Conduritol nucleus Biocatalysis |
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