Structure effect of TsDPEN derivatives on enantioselectivity of asymmetric transfer hydrogenation |
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| Authors: | Juntao Liu Xingshu Li Albert S.C. Chan |
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| Affiliation: | a School of Pharmaceutical Science, Sun Yat-Sen University, Guangzhou 51006, China
b Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China |
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| Abstract: | TsDPEN derivative (3,3′,5,5′-TMTsDPEN) was synthesized and applied in asymmetric transfer hydrogenation of ketones. The influence of chiral ligands’ NCCN dihedral angles to the enantioselectivities of the reaction was discussed. |
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| Keywords: | TMTsDPEN DFT Dihedral angel Enantioselectivity Asymmetric transfer hydrogenation |
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