Synthesis of ferrocenyl quinolines |
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| Authors: | Metin Zora,Ö zlem Velio?lu |
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| Affiliation: | Department of Chemistry, Faculty of Arts and Sciences, Middle East Technical University, 06531 Ankara, Turkey |
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| Abstract: | A convenient one-pot synthesis of ferrocenyl-substituted quinolines via a molecular iodine-catalyzed reaction of ferrocenylimines with enolizable aldehydes is reported. First, nucleophilic addition of the in situ generated enol to ferrocenylimine produces β-anilinopropionaldehyde, which then undergoes intramolecular Friedel-Crafts reaction to give dihydroquinoline derivative. Finally, subsequent dehydration and aerobic oxidation affords ferrocenyl quinolines. |
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| Keywords: | Quinoline Ferrocene Iodine Imine Schiff base Aldehyde |
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