Synthesis,structural characterization,oxygen sensitivity,and antimicrobial activity of ruthenium(II) carbonyl complexes with thiosemicarbazones

Ru(CO)(PPh₃)₂(η³-O,N³,S-TSC¹)] (1), Ru(Cl)(CO)(PPh₃)₂(η²-N³,S-TSC²)] (2), and Ru(Cl)(CO)(PPh₃)₂(η²-N³,S-TSC³)] (3) have been prepared by reacting Ru(H)(Cl)(CO)(PPh₃)₃] with the respective thiosemicarbazones TSC¹ (2-hydroxy-3-methoxybenzaldehyde thiosemicarbazone), TSC² (3-hydroxybenzaldehyde thiosemicarbazone), and TSC³ (3,4-dihydroxybenzaldehyde thiosemicarbazone) in a 1?:?1 M ratio in toluene and all of the complexes have been characterized by UV–vis, FT-IR, and ¹H and ³¹P NMR spectroscopy. The spectroscopic studies showed that TSC¹ is coordinated to the central metal as a tridendate ligand coordinating via the azomethine nitrogen (C=N), phenolic oxygen, and sulfur to ruthenium in 1, whereas TSC² and TSC³ are coordinated to ruthenium as a bidentate ligand through azomethine nitrogen (C=N) and sulfur in 2 and 3. Oxygen sensitivities of 1–3 and Ru(Cl)(CO)(PPh₃)₂(η²-N³,S-TSC⁴)] (4), and antimicrobial activities of 1–3 have been determined.