Synthesis,structural characterization and biological activity of polyoxometallate-containing protonated amantadine as a cation

A novel isopolyoxomolybdate complex (C₁₀H₁₈N)₄Mo₈O₂₆·6(CH₃)₂SO 1 was synthesized, purified and characterized by means of elemental analysis, IR and ¹H NMR spectra and single-crystal X-ray diffraction. It crystallizes in a triclinic system with a?=?11.5090(6), b?=?12.8399(3), c?=?14.774(13)?Å, α?=?105.390(16), β?=?93.09(4), γ?=?106.100(10)°, V?=?2003.1(2)?ų, Z?=?2, R1?=?0.0789, wR2?=?0.2190. Complex 1 is constructed from [Mo₈O₂₆]^4?, (C₁₀H₁₈N)⁺ and (CH₃)₂SO and extends to form a two-dimensional network via hydrogen bonds and weak interactions in the ab plane. Chicken embryo experiments show that Compound 1 has high antiviral activity in vitro.