Synthesis,structure, and DNA binding of three reduced amino-acid Schiff-base zinc(II), nickel(II), and cadmium(II) complexes |
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Abstract: | Three new reduced amino-acid Schiff-base complexes, Zn(HL)2] · H2O (1), Ni(HL)2] · H2O (2), and Cd(HL)2] · H2O (3), where H2L is a reduced Schiff base derived from condensation of N-(2-hydroxybenzaldehyde) and L-histidine, have been synthesized and characterized by elemental analysis, UV-Vis absorption spectra and single crystal X-ray diffraction. Complexes 1–3 are isostructural. All metal centers are six-coordinate with O2N4 donor sets in slightly distorted octahedra. Unlike its Schiff-base counterpart, the deprotonated monoanionic ligand HL? has a more flexible backbone and two HL? are tridentate to one metal. Moreover, the binding interactions of these complexes with calf thymus DNA (CT-DNA) have been investigated by UV-Vis spectra and fluorescence quenching, which show that the complexes bind in an intercalative mode. |
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Keywords: | Transition metal complex Crystal structure Reduced Schiff base DNA binding |
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