| Abstract: | The synthesis, structure, physico-chemical investigation and biological studies of some metal complexes of thiocarbohydrazone ligands are described. The ligands were obtained by condensation of N,N′-thiocarbohydrazide with carbonyl compounds such as 2-hydroxyacetophenone or 5-chlorosalicylaldehyde. A variety of binuclear or mononuclear complexes were obtained with the ligands in mono-, bi- and/or tri-deprotonated forms. The bonding sites are the azomethine nitrogen atom, phenolic oxygen atom and thiol sulfur atom. The metal complexes exhibit either tetrahedral or octahedral structures. Preliminary antimicrobial screening showed that the ligands and their metal complexes possess antimicrobial activity towards bacteria and fungi. |
