Transition metal complexes of 3-acetylpyridine 4 N-(2-pyridyl)thiosemicarbazone (HAPS); structural,spectroscopic, and biological studies

This work examines transition metal ion complexes which have been synthesized from 3-acetylpyridine ⁴ N-(2-pyridyl)thiosemicarbazone (HAPS) (1). Cu(HAPS)₂Cl₂]?·?H₂O (2), Hg(HAPS)₂Cl₂] (3), Ni(HAPS)Cl₂]?·?2H₂O (4), UO₂(APS)₂]?·?2H₂O (5), VO(HAPS)₂]SO₄?·?H₂O (6), and Zn(HAPS)₂Cl₂] (7) were characterized by elemental analysis, spectral (IR, ¹H-NMR, and UV-Vis), magnetic, and molar conductance measurements. The biochemical studies showed that 2 and 3 have powerful and complete degradation on both DNA and protein. Complexes 2, 4, and 7 showed significant antioxidant properties, especially scavenging on superoxide and hydroxyl radicals. The antibacterial screening demonstrated that all studied complexes have maximum and broad range activities against Gram-positive and Gram-negative bacterial strains.