Syntheses,crystal structures,and DNA-binding of some nickel(II) complexes of 1,3-bis(2-pyridylmethylthio)propane and pseudohalides |
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Abstract: | A series of neutral octahedral nickel(II) complexes of 1,3-bis(2-pyridylmethylthio)propane (L) and pseudohalide (X), formulated as [NiII(L)X2] (where X?=?azide (1), cyanate (2), and isothiocyanate (3)), was synthesized. The complexes were characterized by physico-chemical and spectroscopic methods, and 1 and 3 also by single-crystal X-ray diffraction analyses. The structural study shows nickel in a distorted octahedral geometry comprised of the tetradentate NSSN ligand with trans pyridines and monocoordinated pseudohalides in cis positions. In dimethylformamide solution, the complexes had quasi-reversible NiII/NiIII redox couples in cyclic voltammograms with E 1/2 values of +0.732, +0.747, and +0.815?V for 1, 2, and 3, respectively. To examine the biological activities of these complexes, interaction of 3 with calf thymus DNA was studied spectroscopically, showing groove-binding interaction. |
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Keywords: | Nickel(II) complex Crystal structure DNA-binding study |
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