Synthesis,characterization, semi-empirical study,and biological activities of organotin(IV) and transition metal complexes with o-methyl carbonodithioate |
| |
Abstract: | Three transition metal and six organotin(IV) complexes have been synthesized by treating potassium o-methyl carbonodithioate with ZnCl2/CdCl2/HgCl2 and R2SnCl2/R3SnCl under stirring. The complexes were characterized by IR, 1H, and 13C NMR spectroscopies. IR results show that the ligand is bidentate in 1–3 while monodentate in 4–9, which is also confirmed by semi-empirical study. NMR data reveal four-coordinate geometry in solution. HOMO–LUMO study shows that 7 and 9 are thermodynamically unstable. The enzyme inhibition study shows that 1 is a potent inhibitor of ALP, EC 3.1.3.1, resulting in very slow rate of formation and breakdown of enzyme–substrate complex. UV/visible spectroscopy was used to assess the mode of interaction and binding of the complexes with DNA which shows that 9 exhibits higher binding constant when compared to 6. In protein kinase inhibition assay, 1 was active, while antifungal activity shows that organotin(IV) complexes are more active than transition metal complexes. |
| |
Keywords: | o-Methyl carbonodithioate Transition metal complexes Organotin(IV) IR NMR Semi-empirical study HOMO–LUMO calculations Enzyme inhibition study DNA interaction Antifungal activity |
|
|