Synthesis and in vitro anticancer properties of a novel neodymium(III) complex containing tungstogermanate and 5-fluorouracil

Abstract

A novel neodymium(III) complex containing tungstogermanate and 5-fluorouracil, K₁₁(C₄H₄FN₂O₂)₂Nd(GeW₁₁O₃₉)₂·15H₂O (FNdGeW), was synthesized and its structure was characterized by ¹H NMR, IR, XRD, and TG-DSC. The results indicated that FNdGeW had Keggin structure of hetereopolyanion and structure of 5-fluorouracil. The thermal analysis showed that FNdGeW decomposed at 255.3 °C. MTT tests were performed to study the anticancer activities against SGC-7901 and HepG2 cells. The results showed that FNdGeW and FGeW possessed higher anticancer activities than 5-fluorouracil. FNdGeW exhibited the highest anticancer activities against SGC-7901 cells (IC₅₀ = 0.79 μmol?L^-1) and HepG2 cells (IC₅₀ = 0.37 μmol?L^-1).