Design and synthesis of triazole Schiff bases and their oxovanadium(IV) complexes as antimicrobial agents

A new class of triazole Schiff bases have been prepared by the reaction of 3,5-diamino-1,2,4-triazole with methyl-, chloro-, and nitro-substituted furan-2-carboxaldehydes in an equimolar ratio (1?:?1). The bidentate ligands were characterized by IR, ¹H-, and ¹³C-NMR, microanalysis, and mass spectrometry. The Schiff bases were complexed with vanadyl(IV) sulfate in a molar ratio (M?:?L) 1?:?2, M(L)₂]SO₄ (where L?=?L¹–L⁵ and M?=?V^IVO) in a square-pyramidal geometry. In vitro antibacterial activity was determined by screening the compounds against four Gram-negative (Escherichia coli, Shigella flexenari, Pseudomonas aeruginosa, and Salmonella typhi) and two Gram-positive (Staphylococcus aureus and Bacillus subtilis) bacterial strains and in-vitro antifungal activity was carried out on Trichophyton longifucus, Candida albican, Aspergillus flavus, Microscopum canis, Fusarium solani, and Candida glaberata strains.