Fast, flexible algorithm for calculating photon correlations |
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Authors: | Laurence Ted A Fore Samantha Huser Thomas |
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Institution: | Physical Biosciences Institute, Chemistry and Materials Science Directorate, Lawrence Livermore National Laboratory, Livermore, California 94550, USA. laurence2@llnl.gov |
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Abstract: | We introduce a new algorithm for computing correlations of photon arrival time data acquired in single-molecule fluorescence spectroscopy and fluorescence correlation spectroscopy (FCS). The algorithm is based on rewriting the correlation as a counting operation on photon pairs and can be used with arbitrary bin widths and spacing. The flexibility of the algorithm is demonstrated by use of FCS simulations and single-molecule photon antibunching experiments. Execution speed is comparable to the commonly used multiple-tau correlation technique. Wide bin spacings are possible that allow for real-time software calculation of correlations, even for high count rates. |
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