Direct arylation of oxazoles at C2. A concise approach to consecutively linked oxazoles |
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Authors: | Flegeau Emmanuel Ferrer Popkin Matthew E Greaney Michael F |
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Institution: | University of Edinburgh, School of Chemistry, Joseph Black Building, King's Buildings, West Mains Road, Edinburgh, EH9 3JJ, UK. |
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Abstract: | The synthesis of bis- and trisoxazoles via direct arylation is discussed. A variety of aryl groups can be installed at the 2-position of 5-aryl and 5-carboxy-substituted oxazoles under mild conditions using palladium catalysis on water. The direct arylation method can be extended to the synthesis of bis- and trisoxazoles if 2-triisopropylsilyl-4-iodooxazole is used as the electrophile in the arylation. |
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