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5-Chloro-8-quinolyl group as high efficient phosphate protecting group for the synthesis of oligoribonucleotides |
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| Authors: | Hiroshi Takaku Ryuichi Yamaguchi Tadaaki Nomoto Tsujiaki Hata |
| Affiliation: | Laboratory of Organic Chemistry, Chiba Institute of Technology, Narashino-shi, Chiba 275 Japan;Department of Life Chemistry, Tokyo Institute of Technology, Nagatsuta, Midoriku, Yokohama 227, Japan |
| Abstract: | 5-Chloro-8-quinolyl group is found to be very suitable for the protecting group on phosphates in the internucleotidic bonds. The oligoribonucleotides were obtained in good yields by a simple procedure using this phosphate protecting group. |
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