Syntheses and conformational analyses of the perhydrofuro[2,3-b]furan compounds by using lanthanide shift reagent and empirical force-field calculation |
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| Authors: | Yasuhiro Kojima Natsuki Kato Yukimasa Terada |
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| Affiliation: | Department of Agricultural Chemistry, Nagoya University, Chikusa-ku, Nagoya, Japan;Faculty of Pharmacy, Meijo University, Tenpaku-ku, Nagoya, Japan |
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| Abstract: | 1-t-Butyl-7-hydroxyperhydrofuro[2,3-b]furan was synthesized via a furan-alcohol which was derived by a coupling reaction with an epoxide and a new reagent, Li di(3-furyl)cuprate. The configuration of the t-butyl substituent and the conformation of the furo[2,3-b]furan ring were decided by the combination of the LIS experiment and the empirical force-field calculation. |
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