Stereochemistry of two-phase and substrate-reagent ion-pair reactions of betylates: complete inversion in the synthesis of halogen,sulfur, and nitrogen derivatives from R-(-)-2-octanol |
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Authors: | J.F. King M. Aslam J.D. Lock |
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Affiliation: | Department of Chemistry, University of Western Ontario London, Ontario, Canada, N6A 5B7 |
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Abstract: | Conversion of a chiral secondary alcohol into a chiral halogen, sulfur or nitrogen derivative may be conveniently carried out by way of a “betylate” ester. The overall reaction gives reasonable (40–40%) yields with high stereoselectivity (100% inversion in seven or eight examples). |
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