The mechanism of acetoacetate coupling in the biosynthesis of hygrine |
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| Authors: | Brian A. McGaw Jack G. Woolley |
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| Affiliation: | 1. Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, U.S.A.;2. School of Pharmacy, Leicester Polytechnic, Leicester LE1 9BH, England |
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| Abstract: | Sodium[3-14C]- and [4-14C]-acetoacetate were wick fed to 3-month-old Nicandra physaloides plants. The hygrine was isolated and by degradation it was shown that acetoacetate is a precursor. It was also shown that the C(2) carbon is the reactive site in its condensation with the N-methyl-Δ′-pyrrolinium cation. |
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