Intramolecular cyclization of nerol and the related (<span class="math"><math><mtext>z</mtext></math></span>)-allylic alcohols by means of TiCl<sub>4</sub>-PhNHMe complex. Synthesis of nezukone期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Intramolecular cyclization of nerol and the related ( $z$ )-allylic alcohols by means of TiCl₄-PhNHMe complex. Synthesis of nezukone

Authors:	Tadashi Saito Akira Itoh Koichiro Oshima Hitosi Nozaki

Institution:	Department of Industrial Chemistry, Faculty of Engineering Kyoto University, Yoshida, Kyoto 606, Japan

Abstract:	Nerol is cyclized to terpinyl chloride or bromide in the presence of TiX₄-PhNHMe (1:1) complex in dichloromethane at ?23 °C, while cyclization of ( $Z$ )-allylic alcohols CH₂=CR-CH₂CH₂CMe=CHCH₂OH (R = H, Me, Cl) produces seven-membered ring products in fair yields.

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