| 抗肿瘤活性四氢异喹啉生物碱全合成研究进展 |
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| 引用本文： | 廖祥伟,董文芳,刘伟,陈世智,刘站柱. 抗肿瘤活性四氢异喹啉生物碱全合成研究进展[J]. 有机化学, 2010, 30(3): 317-329 |
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| 作者姓名： | 廖祥伟 董文芳 刘伟 陈世智 刘站柱 |
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| 作者单位： | 中国医学科学院北京协和医学院药物研究所,北京,100050 |
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| 基金项目： | 国家自然科学基金，北京市自然科学基金，教育部博士点基金 |
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| 摘 要： | 综述了近年来抗肿瘤活性四氢异喹啉生物碱Renieramycin,Ecteinascidin和Quinocarcin的全合成研究进展,对其构环顺序和方法进行了分析,对部分合成路线的优缺点进行了讨论.
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| 关 键 词： | 四氢异喹啉生物碱 Renieramycins Ecteinascidins Quinocarcin 全合成 |
| 收稿时间： | 2008-11-13 |
| 修稿时间： | 2009-06-20 |
Synthetic Progress of the Tetrahydroisoquinoline Antitumor Alkaloids |
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| Liao Xiangwei,Dong Wenfang,Liu Wei,Chen Shizhi,Liu Zhanzhu. Synthetic Progress of the Tetrahydroisoquinoline Antitumor Alkaloids[J]. Chinese Journal of Organic Chemistry, 2010, 30(3): 317-329 |
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| Authors: | Liao Xiangwei Dong Wenfang Liu Wei Chen Shizhi Liu Zhanzhu |
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| Affiliation: | (Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050) |
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| Abstract: | The recent advance in the total synthesis of the tetrahydroisoquinoline alkaloids is reviewed, including renieramycins, ecteinascidins and quinocarcin. The strategies and sequences to construct the skeleton have been analyzed. Some advantages or limitations of the synthetic routes have also been discussed. |
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| Keywords: | tetrahydroisoquinoline alkaloid renieramycin ecteinascidin quinocarcin total synthesis |
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