| Mn2＋-NaY型分子筛作为口服胃肠道MRI造影剂的研究 |
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| 引用本文： | 李伟生,李中峰,景凤英,杨向光,李晓晶,裴奉奎,王旭霞,雷皓. Mn2＋-NaY型分子筛作为口服胃肠道MRI造影剂的研究[J]. 化学学报, 2007, 65(18): 2029-2033 |
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| 作者姓名： | 李伟生 李中峰 景凤英 杨向光 李晓晶 裴奉奎 王旭霞 雷皓 |
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| 作者单位： | 1. 中国科学院长春应用化学研究所,国家电化学和光谱研究分析中心,绿色化学与过程实验室,长春,130022
2. 中国科学院武汉物理与数学研究所,波谱与原子分子物理国家重点实验室,武汉,430071 |
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| 基金项目： | 波谱与原子分子物理国家重点实验室和长春市科技计划项目 |
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| 摘 要： | 用离子交换法制备了Mn2＋交换的NaY分子筛MnNaY, 用红外光谱(IR)和X射线粉末衍射(XRD)等方法进行了表征. 研究了Mn2＋含量为3.2%的样品在酸性水溶液中的稳定性和离子交换选择性. 弛豫时间测量和体内磁共振成像实验表明其弛豫效率变化范围为4.9～9.7 mmol•L•s－1, 高于目前临床所用造影剂Gd-DTPA, 对胃部MRI信号具有良好的增强效果. 它是比较好的潜在口服胃肠道造影剂.
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| 关 键 词： | 磁共振成像 NaY分子筛 造影剂 弛豫效率 锰(II) |
| 收稿时间： | 2007-01-29 |
| 修稿时间： | 2007-01-29 |
Zeolites Mn2+-NaY as Oral Gastrointestinal Tract Contrast Agents in Magnetic Resonance Imaging |
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| LI,Wei-Sheng,LI,Zhong-Feng,JING,Feng-Ying,YANG,Xiang-Guang,LI,Xiao-Jing,PEI,Feng-Kui,WANG,Xu-Xia,LEI,Hao. Zeolites Mn2+-NaY as Oral Gastrointestinal Tract Contrast Agents in Magnetic Resonance Imaging[J]. Acta Chimica Sinica, 2007, 65(18): 2029-2033 |
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| Authors: | LI Wei-Sheng LI Zhong-Feng JING Feng-Ying YANG Xiang-Guang LI Xiao-Jing PEI Feng-Kui WANG Xu-Xia LEI Hao |
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| Affiliation: | (National Research and Analysis Center of Electrochemistry and Spectroscopy, Green Chemistry and Process Laboratory, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022)(Laboratory of Resonance & Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071) |
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| Abstract: | Mn2＋-loaded zeolites were prepared by ion-exchange of NaY with MnCl2 and characterized by IR and XRD. The stability of MnNaY (3.2% Mn) at low pH and in the presence of metal ions at a concentration relevant to the gastrointestinal tract has been evaluated. The T1-relaxivities of MnNaY decreased as the Mn2＋ loading increased from 3.2% to 5.2%, with values ranging between 4.9 and 9.7 mmol•L•s－1 at 400 MHz and 23 ℃. T1-weighted magnetic resonance imaging (MRI) of rats’ abdomen showed a remarkable enhancement after oral administration of MnNaY (3.2% Mn). The results indicate that the MnNaY may be a potential gastrointestinal tract contrast agent for MRI. |
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| Keywords: | magnetic resonance imaging NaY zeolite contrast agent relaxivity manganese(II) |
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