Synthesis of the dysiherbaine tetrahydropyran core utilizing improved tethered aminohydroxylation conditions |
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Authors: | Carroll Christopher L Chamberlin A Richard |
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Institution: | Department of Chemistry, University of California, Irvine, CA 92697, USA |
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Abstract: | A concise stereoselective route to the dysiherbaine tetrahydropyran core was achieved in nine steps and 39% overall yield. Donohoe’s improved tethered aminohydroxylation conditions were employed to concurrently install the amino and alcohol groups and construct the tetrahydropyran ring, which features four contiguous cis-stereocenters. |
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