Acetals of lactams and acid amides. 53. Eamidines in the synthesis of pyridine and pyrimidine |
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Authors: | E N Dozorova N P Solov'eva V G Granik |
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Institution: | (1) Ordzhonikidze All-Union Scientific Research Chemical Pharmaceutical Institute, 119021 Moscow |
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Abstract: | The reaction of -cyano- -aminocrotonic ester with DMFA diethylacetal gives 1-ethoxycarbonyl-1-cyano-2-(N-dimethylaminomethylene)-amino-4-dimethylaminobutadiene, the reaction of which with ammonium acetate and amines leads to 4-methylenepyrimidine derivatives. Condensation of -cyano- -aminocrotonic ester with dimethylacetamide dieethylacetal gave 2-(ethoxycarbonylcyano)methylene-4-dimethylamino-6-methylpyridine. It was found that in an alkaline medium, 1-benzyl-4-(ethoxycarbonylcyano) methylenepyrimidine recyclizes into 1-benzyl-3-cyano-4-amino-2-pyridone.For Communication 52, see 1].Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1109–1114, August, 1988. |
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