A facile route for the synthesis of vinyl-substituted 1,3,4-oxadiazoles |
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Authors: | Santosh P Pardeshi Sachin S Patil Amar A Patil Vivek D Bobade |
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Institution: | 1. Department of Chemistry, HPT Arts and RYK Science College, Nasik, India
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Abstract: | An efficient synthesis of vinyl-substituted 1,3,4-oxadiazoles using o-nitrophenyl sulfoxide precursor via syn-elimination reaction using sodium acetate in THF is described. This method is cost effective as it uses cheap o-nitrothiophenol and can be used in the synthesis of vinyl intermediates during synthesis of bioactive compounds, which avoids the use of any toxic metals. |
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