Palladium-catalyzed oxidative C-H bond coupling of steered acetanilides and aldehydes: a facile access to ortho-acylacetanilides |
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| Authors: | Wu Yinuo Li Baozhu Mao Fei Li Xingshu Kwong Fuk Yee |
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| Affiliation: | School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. |
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| Abstract: | A palladium-catalyzed oxidative C-H bond functionalization/ortho-acylation of acetanilides using easily accessible aldehyde as the acyl source is described. In the presence of a Pd(TFA)(2) catalyst and tert-butylhydroperoxide at 90 °C in general, an array of ortho-acylacetanilides can be afforded in good yields. |
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