Assembling ligands in situ using bioorthogonal boronate ester synthesis |
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Authors: | Shin Sung Bin Y Almeida Ramiro D Gerona-Navarro Guillermo Bracken Clay Jaffrey Samie R |
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Affiliation: | Department of Pharmacology, Weill Medical College, Cornell University, New York, NY 10065, USA. |
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Abstract: | Many molecules that could manipulate cellular function are not practical due to their large size and concomitant undesirable pharmocokinetic properties. Here, we describe a bioorthogonal, highly stable boronate ester (HiSBE) synthesis and use this reaction to synthesize a biologically active molecule from smaller precursors in a physiological context. The rapid rate of HiSBE synthesis suggests that it may be useful for assembling a wide variety of biologically active molecules in physiological solutions. |
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