| Purification,Characterization and ~1H NMR Resonance Assignment of an α-Like Neurotoxin BmK 16 from the Venom of Chinese Scorpion Buthus martensii Karsch |
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| 作者姓名： | 张乃霞 吴宫 王中华 吴厚铭 |
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| 作者单位： | State Key Laboratory of Bioorganic and Natural Products Chemistry，State Key Laboratory of Bioorganic and Natural Products Chemistry，State Key Laboratory of Bioorganic and Natural Products Chemistry，State Key Laboratory of Bioorganic and Natural Products Chemistry Shanghai Institute of Organic Chemistry，Chinese Academy of Sciences，Shanghai 200032，China，Shanghai Institute of Organic Chemistry，Chinese Academy of Sciences，Shanghai 200032，China，Shanghai Institute of Organic Chemistry，Chinese Academy of Sciences，Shanghai 200032，China，Shanghai Institute of Organic Chemistry，Chinese Academy of Sciences，Shanghai 200032，China |
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| 基金项目： | ProjectsupportedbytheNationalNaturalScienceFoundationofChina (No .2 0 13 2 0 3 0 ) |
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| 摘 要： | IntroductionThescorpionvenomsarerichsourceoffascinatingpeptides,whichusuallycomposedof 2 8— 70aminoacidresidues.TheyinteractspecificallywiththeNa+,K+,Ca2 +orCl- ionchannelsandarewidelyservedasusefultoolsinprobingtheproteinmappingofionchannelsandclarifyingthemolecularmechanisminvolvedinthesignaltransmissionandchannelgating .Thelong chainneurotox inpolypeptides (6 2— 6 7aminoacidresidues)isolatedfromscorpionscanbedividedintotwoclasses ,α andβ toxins ,onthebasisoftheireffectsonthesodiumchan…
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| 关 键 词： | scorpion toxin Buthus martensii Karsch BmK 16 αlike scorpion neurotoxin amino acid sequence resonance assignment |
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