广东石豆兰中的噁庚英和联苄类化合物

从兰科植物广东石豆兰(Bulbophyllum kwangtungense Schlecht.)的乙酸乙酯部分分离得到了2个新的茋类化合物5-(2,3-二甲氧苯乙基)-6-甲基苯并d]1,3]二氧戊环(1)和10,11-二氢-2,7-二甲氧基-3,4-亚甲二氧基二苯并b,f]噁庚英(2). 药理活性实验结果证明, 化合物2对体外培养的Hela细胞有较强的抑制作用.

Oxepine and Bibenzyl Compounds from Bulbophyllum kwangtungense

Phytohemical investigation of the EtOAc extract of leaves and stems of Bulbophyllum kwangtungense Schlecht., belonging to the orchid family was carried out. Two new stilbenods were isolated by repeat column chromatography and characterized: one is bibenzyl compound, 5-(2,3-dimethoxyphenethyl)-6-methylbenzod]1,3]dioxole(1), and the other dibenzb,f]oxepine, 10,11-dihydro-2,7-dimethoxy-3,4-methylene-dioxy dibenzob,f]oxepine(2). Their structures were established on the basis of analyses of spectroscopic evidence, particularly by two-dimensional NMR spectroscopic analysis. Bibenzyl compound with a methyl group in the benzene ring is rarely found from natural sources. Natural oxepines are very rare, and most of them were reported to have good anti-tumor activities. In addition, anti-tumor activities of the new compounds were also evaluated. Among the compounds isolated, compound 2 showed anti-tumor activities with IC50 value of 47.2 μg/mL in vitro against cultures of Hela cells.