| 去甲斑蝥素四甲酸甲酯的合成工艺研究 |
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| 引用本文： | 崔晗琦,王先恒,王玉和,吴朝远,普悦,赵长阔,郭伟航,周亦琪.去甲斑蝥素四甲酸甲酯的合成工艺研究[J].化学研究与应用,2020,32(1):123-127. |
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| 作者姓名： | 崔晗琦 王先恒 王玉和 吴朝远 普悦 赵长阔 郭伟航 周亦琪 |
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| 作者单位： | 遵义医科大学,基础药理教育部重点实验室暨特色民族药教育部国际合作联合实验室,贵州 遵义 563000;遵义医科大学药学院,贵州 遵义 563000;遵义医科大学药学院,贵州 遵义 563000;遵义医科大学附属医院,贵州 遵义 563000 |
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| 基金项目： | 贵州省科技厅项目;遵义医学院招标项目 |
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| 摘 要： | 聚酰亚胺是一类综合性能优异的耐高温胶黏剂,被广泛应用于航空航天及电子等高科技领域。去甲斑蝥素四甲酸单体进行聚合的聚酰亚胺可以降低分子刚性,这一特点引起了人们的注意。本文分别从钯催化剂的种类、CuCl2试剂的规格以及溶剂的级别等方面进行优化,最终发现在10%Pd/C,CuCl2试剂以及干燥处理过的甲醇溶剂条件下,以85%的较高收率得到去甲斑蝥素四甲酸甲酯单体。
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| 关 键 词： | 聚酰亚胺 去甲斑蝥素 关键中间体 工艺优化 |
Research on synthetic process of methyl norcantharidin tetraformate |
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| CUI Han-qi,WANG Xian-heng,WANG Yu-he,WU Chao-yuan,PU Yue,ZHAO Chang-kuo,GUO Wei-hang,ZHOU Yi-qi.Research on synthetic process of methyl norcantharidin tetraformate[J].Chemical Research and Application,2020,32(1):123-127. |
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| Authors: | CUI Han-qi WANG Xian-heng WANG Yu-he WU Chao-yuan PU Yue ZHAO Chang-kuo GUO Wei-hang ZHOU Yi-qi |
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| Institution: | (Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education,Zunyi Medical University,Zunyi 563000,China;Pharmacy School,Zunyi Medical University,Zunyi 563000,China;The Affiliated Hospital,Zunyi Medical University,Zunyi 563000,China) |
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| Abstract: | Polyimide is a kind of high temperature resistant adhesive with excellent comprehensive performance and is widely used in high-tech fields such as aerospace and electronics.Polyimide which is polymerized by norcantharidin tetracarboxylic acid monomer has attracted much attention because of its unique property of reducing molecular rigidity.In this work,different types of palladium catalysts,CuCl2 reagents and solvent were optimized respectively.Finally,it was found that norcantharidin tetracarboxylic acid tetraester monomer was smoothly obtained in a ratio of 85%under the condition of 10%Pd/C,CuCl2 and dry methanol. |
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| Keywords: | polyimide norcantharidin key intermediate process optimization |
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