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Pulse sequence for dynamic volumetric imaging of hyperpolarized metabolic products |
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| Authors: | Cunningham Charles H Chen Albert P Lustig Michael Hargreaves Brian A Lupo Janine Xu Duan Kurhanewicz John Hurd Ralph E Pauly John M Nelson Sarah J Vigneron Daniel B |
| Affiliation: | aDepartment of Medical Biophysics and Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ont., Canada M4N 3M5;bDepartment of Radiology, University of California at San Francisco, San Francisco, CA, USA;cDepartment of Electrical Engineering, Stanford University, Stanford, CA, USA;dDepartment of Radiology, Stanford University, Stanford, California, USA;eGE Healthcare Technologies, Menlo Park, CA, USA |
| Abstract: | Dynamic nuclear polarization and dissolution of a 13C-labeled substrate enables the dynamic imaging of cellular metabolism. Spectroscopic information is typically acquired, making the acquisition of dynamic volumetric data a challenge. To enable rapid volumetric imaging, a spectral-spatial excitation pulse was designed to excite a single line of the carbon spectrum. With only a single resonance present in the signal, an echo-planar readout trajectory could be used to resolve spatial information, giving full volume coverage of 32 × 32 × 16 voxels every 3.5 s. This high frame rate was used to measure the different lactate dynamics in different tissues in a normal rat model and a mouse model of prostate cancer. |
| Keywords: | 13C Hyperpolarized Lactate Spectral-spatial Metabolism |
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