Fluorescence of a Benzothienopyridopyrimidone in Solution and in Lipid Vesicles |
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| Authors: | Elisabete M S Castanheira Ana M R Pinto Maria-João R P Queiroz |
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| Institution: | (1) Departamento de Física, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal;(2) Departamento de Química, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal |
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| Abstract: | Fluorescence properties of a biologically active benzothienopyridopyrimidone in solution and in lipid vesicles are reported. Assays at different pH values (0.5–10) allowed the determination of pK
a = 2.0, showing that this compound may be useful as a pH indicator for pH ≤ 4. In lipid vesicles, benzothienopyridopyrimidone locates in a water-rich environment, indicating that it can be carried in the hydrophilic region of liposomes for drug delivery applications. |
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| Keywords: | Benzothienopyridopyrimidone pH probe Lipid vesicles |
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