| 多响应性聚肽共混胶束的药物控释性能 |
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| 引用本文： | 朱健琦,陈涛,林嘉平,林绍梁,蔡春华,张良顺.多响应性聚肽共混胶束的药物控释性能[J].功能高分子学报,2008,21(3). |
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| 作者姓名： | 朱健琦 陈涛 林嘉平 林绍梁 蔡春华 张良顺 |
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| 作者单位： | 华东理工大学材料科学与工程学院,上海,200237 |
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| 基金项目： | 国家自然科学基金，上海市国际科技合作基金，上海市重点学科建设项目 |
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| 摘 要： | 合成了聚(L-谷氨酸)-b-聚氧化丙烯-b-聚(L-谷氨酸)(PLGA-b-PPO-b-PLGA)三嵌段聚肽共聚物.通过透射电镜、激光光散射与核磁共振等方法研究了其与聚乙二醇-6-聚氧化丙烯(PEG-b-PPO)两嵌段共聚物共混体系的自组装行为,使用紫外分光光度计探讨了负载阿霉素的共混聚集体在不同环境下的释药行为.结果表明:该体系形成了以PPO为内核,PLGA和PEG为壳的共混胶束,该共混胶束的释药行为不仅具有pH和温度的响应性,并且对共混胶束的组分具有依赖性.
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| 关 键 词： | 共混胶束 释药 多响应性 聚肽共聚物 |
Controlled Drug Release Properties of Multi-Responsive Hybrid Micelles Based on Polypeptide Copolymers |
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| ZHU Jian-qi,CHEN Tao,LIN Jia-ping,LIN Shao-liang,CAI Chun-hua,ZHANG Liang-shun.Controlled Drug Release Properties of Multi-Responsive Hybrid Micelles Based on Polypeptide Copolymers[J].Journal of Functional Polymers,2008,21(3). |
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| Authors: | ZHU Jian-qi CHEN Tao LIN Jia-ping LIN Shao-liang CAI Chun-hua ZHANG Liang-shun |
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| Institution: | ZHU Jian-qi,CHEN Tao,LIN Jia-ping,LIN Shao-liang,CAI Chun-hua,ZHANG Liang-shun(School of Materials Science , Engineering,East China University of Science ,Technology,Shanghai 200237,China) |
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| Abstract: | Poly(L-glutamic acid)-b-poly(propylene oxide)-b-poly(L-glutamic acid)(PLGA-b-PPO-b-(PLGA,) GPG) was mixed with poly(ethylene glycol)-b-poly(propylene oxide)(PEG-PPO,EP) to form(self-assembling) aggregates.Transmission electron microscopy,dynamic light scattering and nuclear magnetic resonance spectroscopy were used to study the self-assembly behaviors of the mixtures.Ultraviolet spectrometer was used to determine the drug release kinetic of Doxorubicin-loaded aggregates.The experimental results show that th... |
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| Keywords: | hybrid micelle drug release multi-responsive polypeptide copolymer |
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