A practical ruthenium-catalyzed cleavage of the allyl protecting group in amides, lactams, imides, and congeners |
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Authors: | Alcaide Benito Almendros Pedro Alonso Jose M |
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Institution: | Departamento de Química Orgánica I, Facultad de Química, Universidad Complutense de Madrid, 28040 Madrid, Spain. alcaideb@quim.ucm.es |
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Abstract: | A convenient methodology for the deprotection of N-allylic amide-like moieties was developed. The first examples accounting for the ruthenium-catalyzed deallylation of amides, lactams, imides, pyrazolidones, hydantoins, and oxazolidinones have been achieved by the sequential use of Grubbs carbene (isomerization step) and RuCl(3) (oxidation step). A variety of substrates, including enantiopure multifunctional beta- and gamma-lactams, can be employed. |
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Keywords: | amides cleavage reactions lactams protecting groups ruthenium |
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