含胆酸高分子化合物的制备和特性*

胆酸是哺乳动物体内合成的一种天然化合物，具有特殊的分子结构和优良的生物适应性。由胆酸合成的高分子化合物保持了胆酸的部分性质，如双亲性、手性、侧基反应活性和自组装性能等。在化学和药学领域，含胆酸高分子材料具有重要的应用价值。本文从自由基聚合形成的含胆酸高分子化合物、胆酸修饰的高分子化合物和胆酸聚合物等几个方面综述了含胆酸高分子化合物的制备和特性，并对胆酸在高分子材料方面的新用途作了展望。

Preparation and Characterization of Polymers Containing Cholic Acid Moiety

Cholic acid is a natural compound that is synthesized in the animal body, which has special chemical structure and good biocompatibility. Polymers prepared from cholic acid can preserve some properties of cholic acid, such as facial amphiphilicity, chirality, reactivity of the side groups and capacity of self-assembling. In chemical and pharmaceutical fields, polymeric materials containing cholic acid can be used widely. This paper reviews the preparation and characterization of polymers containing cholic acid obtained by free radical polymerization, polymers modified with cholic acid and polycondensation of cholic acid, etc. The development of polymers containing cholic acid in the future is also forecasted. Contents
1 Introduction
2 Polymeric materials containing cholic acid obtained by radical polymerization
2.1 Polymers obtained from polymerization of vinylic group at position C3
2.2 Polymers obtained from polymerization of vinylic group at position C24
2.3 Polymers obtained from polymerization of vinylic groups at positions C3,C7 and C12
3 Polymers obtained from chemical modify with cholic acid
3.1 Polymers with cholic acid moieties as side group
3.2 Polymers end-capped with cholic acid
4 Polycondensation of cholic acid
5 Molecular umbrellas
6 Dendritic polymer
7 Applications of cholic acid on other fields
8 Conclusions