Meroterpenes from an algicolous strain of Penicillium echinulatum |
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| Authors: | Xiao‐Dong Li Feng‐Ping Miao Xiao‐Rui Liang Nai‐Yun Ji |
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| Affiliation: | 1. Key Laboratory of Coastal Biology and Bioresource Utilization, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, , Yantai, 264003 China;2. Naval Aeronautical and Astronautical University, , Yantai, 264001 China |
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| Abstract: | One new meroterpene, arisugacin K (1), and four known ones, arisugacin J (2), arisugacin G (3), arisugacin C (4), and territrem C (5), were isolated from the culture of Penicillium echinulatum pt‐4, an endophytic fungus isolated from the marine red alga Chondrus ocellatus. The structure and the absolute configuration of 1 were unambiguously elucidated by spectroscopic analyses and quantum chemical calculations, which further resulted in the assignments of absolute configurations for the other arisugacins and territrems. Compound 1 showed inhibitory activity against Escherichia coli with an inhibition diameter 8 mm at 30 µg/disk and 4 exhibited lethality against Artemia salina with an LC50 of 48.6 µg/ml. Copyright © 2014 John Wiley & Sons, Ltd. |
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| Keywords: | NMR 1H NMR 13C NMR two‐dimensional NMR arisugacin K Penicillium echinulatum |
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