Structure determination of two new indole‐diterpenoids from Penicillium sp. CM‐7 by NMR spectroscopy |
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| Authors: | Yu‐Hong Zhang Sheng‐Dong Huang Hua‐Qi Pan Xi‐Qing Bian Zai‐Ying Wang Ai‐Hong Han Jiao Bai |
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| Affiliation: | 1. Key Laboratory of Structure‐Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, , Shenyang, 110016 China;2. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, , Shenyang, 110016 China;3. Institute of Applied Ecology, Chinese Academy of Sciences, , Shenyang, 110016 China;4. College of Chemistry and Life Science, Shenyang Normal University, , Shenyang, 110034 China |
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| Abstract: | Two new indole‐diterpenoids 4b‐deoxy‐1′‐O‐acetylpaxilline (1) and 4b‐deoxypenijanthine A (2) were isolated from the fermentation broth and the mycelia of the soil fungus Penicillium sp. CM‐7, along with three known structurally related compounds, 1′‐O‐acetylpaxilline (3), paspaline (4) and 3‐deoxo‐4b‐deoxypaxilline (5). The structures of compounds 1 and 2 were elucidated by extensive spectroscopic methods, especially 2D NMR, and their absolute configurations were suggested on the basis of the circular dichroism spectral analysis and the NOESY data. Copyright © 2014 John Wiley & Sons, Ltd. |
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| Keywords: | NMR 1H NMR 13C NMR Indole‐diterpenoids Penicillium sp |
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