Performance analysis of a swept-source optical coherence tomography system with a quadrature interferometer and optical amplification |
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| Authors: | Youxin Mao Costel Flueraru Shoude Chang Dan P Popescu Michael G Sowa |
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| Institution: | 1. Institute for Microstructural Sciences, National Research Council Canada, 1200 Montreal Rd, Ottawa, ON, Canada K1A 0R6;2. Institute for Biodiagnostics, National Research Council Canada, 435 Ellice Avenue, Winnipeg, MB, Canada R3B 1Y6;1. Operative Endoscopy Department, Campus Bio-Medico University Hospital, Rome, Italy;2. Pathology Unit, Campus Bio-Medico University Hospital, Rome, Italy;3. Endoscopy Unit, Nuovo Regina Margherita Hospital, Rome, Italy;4. Department of Urology, Campus Bio-Medico University Hospital, Rome, Italy;1. Jo?ef Stefan International Postgraduate School, Jamova cesta 39, SI-1000 Ljubljana, Slovenia;2. Faculty of Electrical Engineering, University of Ljubljana, Tr?a?ka cesta 25, SI-1000 Ljubljana, Slovenia;3. Department of Condensed Matter Physics, Jozef Stefan Institute, Jamova cesta 39, SI-1000 Ljubljana, Slovenia;4. Faculty of Natural Sciences and Mathematics, University of Maribor, Koro?ka cesta 160, SI-2000 Maribor, Slovenia;1. Fischell Department of Bioengineering, Room 2330 Jeong H. Kim Engineering Building, University of Maryland, College Park, MD 20742, USA;2. Department of Materials Science and Engineering, University of Maryland, College Park, MD 20740, USA;1. Ophthalmology Department, Fatebenefratelli and Ophthalmic Hospital, ASST-Fatebenefratelli-Sacco, Milan, Italy;2. Retinal Disorders and Ophthalmic Genetics Division, Stein Eye Institute, University of California, Los Angeles, Los Angeles, California, USA;3. Greater Los Angeles VA Healthcare Center, Los Angeles, California, USA;4. Retina Division, Stein Eye Institute, University of California, Los Angeles, California, USA;5. Ophthalmology Department, AP-HP, Hôpital Lariboisière, Université Paris Diderot, Sorbonne Paris Citè, France;6. Ophthalmology Department, Careggi University Hospital, University of Florence, Florence, Italy;7. Humanitas University, Eye Unit, Humanitas-Gavazzeni Hospital, Bergamo, Italy;1. Department of Ophthalmology, Aichi Medical University, Nagakute, Aichi, Japan;2. Casey Eye Institute, Oregon Health & Science University, Portland, Oregon;3. Mid Atlantic Retina, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania;4. Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan |
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| Abstract: | A performance analysis of signal to noise ratio for an optical coherence tomography system with quadrature detection and a semiconductor optical amplifier in the sample arm is discussed. The results are compared and discussed in relation to a conventional OCT system (without optical amplification). An increase of the signal to noise ratio up to 14 dB at a depth of 0.5 mm is obtained compared to the system without the optical amplifier. Overall, an improvement was demonstrated for signal coming from deeper regions within the samples. Arterial plaque from a myocardial infarction-prone Watanabe heritable hyperlipidemic (WHHLMI) rabbit is visualized and characterized using this system. Improvement of signal to noise ratio increases the penetration depth possible for OCT images, from 1 mm to 2 mm within the vessel wall of an artery. Preliminary results show that vulnerable plaque with fibrous cap, macrophage accumulations and calcification in the arterial tissue are measurable with this OCT system. |
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