A resting state network in the motor control circuit of the basal ganglia |
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Authors: | Simon Robinson Gianpaolo Basso Nicola Soldati Uta Sailer Jorge Jovicich Lorenzo Bruzzone Ilse Kryspin-Exner Herbert Bauer and Ewald Moser |
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Institution: | (1) Functional Neuroimaging Laboratory, Center for Mind/Brain Sciences, University of Trento, Trento, Italy;(2) Telecommunication Engineering, University of Trento, Trento, Italy;(3) Faculty of Psychology, University of Vienna, Liebiggasse 5, 1010 Vienna, Austria;(4) MR Center of Excellence, Medical University of Vienna, Lazarettgasse 14, 1090 Vienna, Austria;(5) Center for Biomedical Engineering and Physics, Medical University of Vienna, W?hringer G?rtel 18-20, 1090 Vienna, Austria |
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Abstract: | Background In the absence of overt stimuli, the brain shows correlated fluctuations in functionally related brain regions. Approximately
ten largely independent resting state networks (RSNs) showing this behaviour have been documented to date. Recent studies
have reported the existence of an RSN in the basal ganglia - albeit inconsistently and without the means to interpret its
function. Using two large study groups with different resting state conditions and MR protocols, the reproducibility of the
network across subjects, behavioural conditions and acquisition parameters is assessed. Independent Component Analysis (ICA),
combined with novel analyses of temporal features, is applied to establish the basis of signal fluctuations in the network
and its relation to other RSNs. Reference to prior probabilistic diffusion tractography work is used to identify the basal
ganglia circuit to which these fluctuations correspond. |
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