| 细胞核凋亡过程中核基质的变化 |
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| 引用本文： | 赵允,沈延,吴蚊,翟中和.细胞核凋亡过程中核基质的变化[J].电子显微学报,2001,20(2):87-92. |
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| 作者姓名： | 赵允 沈延 吴蚊 翟中和 |
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| 作者单位： | 北京大学生命科学学院, |
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| 基金项目： | 国家自然科学基金资助项目!(3980 0 0 75,19890 380 )，国家重大基础研究资助项目!(G19990 5 390 5 ) |
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| 摘 要： | 在非细胞体系中以细胞色素C作为诱导剂，诱导小鼠有细胞核发生凋亡，在透射电子显微镜及扫描电子显微镜下观察到凋亡的一现典型的凋亡形态学特征，整装电镜的结果显示，在凋亡过程中核基质结构被破坏，但核基质结构仍然存在，并最终形成凋亡小体的结构基础。
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| 关 键 词： | 细胞色素C 小鼠肝细胞核 凋亡 核基质 细胞凋亡 透射电镜 扫描电镜 |
| 文章编号： | 1000-6281(2001)02-0093-05 |
The change of nuclear matrix lamina in apoptosis of nucleus |
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| ZHAO Yun,SHEN Yan,WU Min,ZHAI Zhong he.The change of nuclear matrix lamina in apoptosis of nucleus[J].Journal of Chinese Electron Microscopy Society,2001,20(2):87-92. |
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| Authors: | ZHAO Yun SHEN Yan WU Min ZHAI Zhong he |
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| Abstract: | We induced apoptosis of mouse nuclei in cell free system using cytochrome C. The apoptotic nucleus displayed the typical apoptotic character when it was observed under transmission electron microscope and scanning electron microscope. The results of whole mount electron microscopy indicated that nuclear matrix still existed during the course of apoptosis, whereas lamina system was destroyed. It was nuclear matrix that connected the apoptotic bodies and apoptotic nucleus, which laid the structural foundation of apoptotic bodies. |
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| Keywords: | cytochrome C mouse nuclei apoptosis whole mount electron microscopy nuclear matrix lamina |
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