首页 | 本学科首页   官方微博 | 高级检索  
     检索      


New extractive spectrophotometric methods for the determination of nortriptyline hydrochloride in pure form and pharmaceutical dosages
Authors:D H Manjunatha  J Seetharamappa  P B Kandagal  S S Kalanur
Institution:(1) Post-Graduate Department of Studies in Chemistry, Karnatak University, Dharwad, 580003, India
Abstract:Two simple, rapid and sensitive extractive spectrophotometric methods have been developed for the assay of nortriptyline hydrochloride (NTPH) in pure and pharmaceutical formulations. These methods are based on the formation of chloroform soluble ion-association complexes of NTPH with bromocresol green (BCG) and with methyl orange (MO) in KCl-HCl buffer of pH 2. The colored species exhibited absorption maxima at 416 and 422 nm for BCG and MO with molar absorptivity values of 2.88 × 104 and 2.29 × 104 L/mol cm, respectively. Reaction conditions were optimized to obtain the maximum color intensity. Various analytical parameters have been evaluated and the results have been validated by statistical data. The methods were successfully applied to the analysis of NTPH in pharmaceutical formulations. The article is published in the original.
Keywords:
本文献已被 SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号