Neutral desorption extractive electrospray ionization mass spectrometry for fast screening sunscreen agents in cream cosmetic products |
| |
| Authors: | Zhang Xinglei Liu Yan Zhang Jinghua Hu Zhong Hu Bin Ding Liying Jia Li Chen Huanwen |
| |
| Institution: | a Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation, East China Institute of Technology, Nanchang, Jiangxi Province 330013 PR China
b Beijing Center for Physical and Chemical Analysis, Beijing 100089, PR China |
| |
| Abstract: | High throughput analysis of sunscreen agents present in cream cosmetic has been demonstrated, typically 2 samples per minute, using neutral desorption extractive electrospray ionization mass spectrometry (ND-EESI-MS) without sample pretreatment. For the targeted compounds such as 4-Aminobenzoic acid and oxybenzone, ND-EESI-MS method provided linear signal responses in the range of 1-100 ppb. Limits of detection (LOD) of the method were estimated at sub-ppb levels for the analytes tested. Reasonable relative standard deviation (RSD = 8.4-16.0%) was obtained as a result of 10 independent measurements for commercial cosmetics samples spiked with each individual sunscreen agents at 1-10 ppb. Acceptable recoveries were achieved in the range of 87-116% for direct analysis of commercial cream cosmetic samples. The experimental data demonstrate that ND-EESI-MS is a useful tool for high throughput screening of sunscreen agents in highly viscous cream cosmetic products, with the capability to obtain quantitative information of the analytes. |
| |
| Keywords: | Neutral desorption (ND) Extractive electrospray ionization (EESI) Viscous samples Cream Sunscreen agents High throughput analysis |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
