1,4-Benzodiazepines and their cyclic homologs and analogs |
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Authors: | S. A. Andronati A. V. Bogat-skii G. N. Gordiichuk Z. I. Zhilina L. M. Yagupol'skii |
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Affiliation: | 1. Institute of Organic Chemistry, Academy of Sciences of the Ukrainian SSR, I. I. Mechnikov Odessa State University, Kiev
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Abstract: | 5-Difluoromethylsulfonyl-2-aminobenzophenone was synthesized by condensation of p-difluoromethylsulfonylaniline with benzoyl chloride. 5-Difluoromethoxy- and 5-difluoromethylthio-2-aminobenzophenones were obtained by condensation of phenylacetonitrile with the appropriate p-substituted nitrobenzenes and subsequent reduction of the resulting anthranils. 7-Difluoromethoxy-, 7-difluoromethylthio-, and 7-difluoromethylsulfonyl-5-phenyl-1,2-dihydro-3H-1,4-benzodiazepin-2-ones were obtained by the successive action of bromoacetyl bromide and ammonia on the 2-aminobenzophenone derivatives or by reaction of 2-aminobenzophenones with aminoacetyl chloride hydrochloride. The structure of the 1,4-benzodiazepines was confirmed by a study of the UV, IR, PMR, and mass spectra. |
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