Copolymers of ethyl glycolate and ω–pentadecalactone: Enzymatic synthesis and solid-state characterization |
| |
Authors: | Laura Mazzocchetti Mariastella Scandola Zhaozhong Jiang |
| |
Institution: | aUniversity of Bologna, Department of Chemistry “G. Ciamician” and INSTM UdR Bologna, Via Selmi 2, 40126 Bologna, Italy;bBiomedical Engineering Department, Yale University, 55 Prospect Street, New Haven, CT 06511, USA |
| |
Abstract: | Synthesis of poly(PDL-GA) copolymers is successfully achieved via enzymatic catalysis starting from ω-pentadecalactone and ethyl glycolate. In the copolymers PDL and GA units show a significant tendency to an alternating arrangement. All copolyesters display a high degree of crystallinity (χc ≈ 70%) regardless of their composition (GA content: 0–27 mol%). Analysis of melting point depression by the Wendling–Suter model suggests inclusion of GA units in PPDL-type crystals. Accordingly WAXS results show that, with increasing GA unit content, the PPDL unit cell undergoes a gradual increase of c-axis (chain axis) periodicity, compatible with the insertion of GA units within the crystallizing PDL sequences. Poly(PDL-GA) copolymers combine typically hydrophobic (PDL) and hydrophilic (GA) monomers and are promising new tuneable drug-delivery systems for medical applications. In this perspective, poly(PDL-GA) nanoparticles are fabricated and characterized. |
| |
Keywords: | Biocatalysis Copolymer Nanoparticle Thermal properties Cocrystallization |
本文献已被 ScienceDirect 等数据库收录! |
|