Biocompatible cryogels of thermosensitive polyglycidol derivatives with ultra-rapid swelling properties |
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| Authors: | Petar Petrov Alicja Utrata-Weso?ek Barbara Trzebicka Christo B Tsvetanov Andrzej Dworak Jacek Anio? Aleksander Sieroń |
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| Institution: | aInstitute of Polymers, Bulgarian Academy of Sciences, Akad. G. Bonchev Str. 103A, 1113 Sofia, Bulgaria;bCentre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Sklodowskiej 34, Zabrze 41-819, Poland;cDepartment of General, Molecular Biology and Genetics, Medical University of Silesia, Medykow 18, Katowice 40-752, Poland |
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| Abstract: | Novel thermosensitive macroporous cryogels, based on various hydrophobically modified high molar mass (HMM) polyglycidol precursors, were synthesized using the UV-irradiation technique. The method involved the preparation of a semi-dilute aqueous solution of thermosensitive poly(glycidol-co-ethyl glycidyl carbamate) (PGL-Et), subsequent freezing at a moderately negative temperature (−20 °C) and irradiation with UV light. All PGL-Et cryogels had a spongy-like structure of smooth polymer walls surrounding interconnected macroscopic pores. Consequently, the cryogels exhibited temperature triggered, reversible, ultra-rapid volume phase transition (VPT) from a swollen to deswollen state within 20–25 s. The VPT temperature of the PGL-Et cryogels was strongly dependent on the degree of modification of the PGL precursors and it decreased proportionally with increased ethyl glycidyl carbamate content. The PGL-Et cryogels were used as a scaffold for skin cell (fibroblast) adhesion. Adhesion and proliferation tests indicated that the gels were good supports for cell cultivation. |
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| Keywords: | Cryogels Thermosensitivity Cell adhesion Polyglycidol |
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